A nonfunctional halogenase masquerades as an aromatizing dehydratase in biosynthesis of pyrrolic polyketides by type I polyketide synthases
Yi D, Niroula D, Gutekunst WR, Loper JE, Yan Q, Agarwal V*
ACS Chem Biol 2022 Accepted, in press.
PDF
Yi D, Niroula D, Gutekunst WR, Loper JE, Yan Q, Agarwal V*
ACS Chem Biol 2022 Accepted, in press.
A silent biosynthetic gene cluster from a methanotrophic bacterium potentiates discovery of a substrate promiscuous proteusin cyclodehydratase
Nguyet NA, Cong Y, Hurrell RC, Arias N, Garg N, Puri AW, Schmidt EW, Agarwal V*
ACS Chem Biol 2022 Accepted, in press.
PDF
Nguyet NA, Cong Y, Hurrell RC, Arias N, Garg N, Puri AW, Schmidt EW, Agarwal V*
ACS Chem Biol 2022 Accepted, in press.
Resolving the hydride transfer pathway in oxidative conversion of proline to pyrrole
Acharya A, Yi D, Pavlova A, Agarwal V*, Gumbart JC*
Biochemistry 2022 61, 206–215.
PDF
Acharya A, Yi D, Pavlova A, Agarwal V*, Gumbart JC*
Biochemistry 2022 61, 206–215.
Hepatic demethylation of methoxy-bromodiphenyl ethers and conjugation of the resulting hydroxy-bromodiphenyl ethers in a marine fish, the red snapper, Lutjanus campechanus, and a freshwater fish, the channel catfish, Ictalurus punctatus
Sultana A, Hindrichs C, Cisneros KV, Weaver CJ, Faux LR, Agarwal V, ames MO
Chemosphere. 2022 286, 131620.
PDF
Sultana A, Hindrichs C, Cisneros KV, Weaver CJ, Faux LR, Agarwal V, ames MO
Chemosphere. 2022 286, 131620.
An obligate peptidyl brominase underlies the discovery of highly distributed biosynthetic gene clusters in marine sponge microbiomes
Nguyen NA, Lin Z, Mohanty I, Garg N, Schmidt EW, Agarwal V
JACS. 2021 143, 10221-10231
PDF
Nguyen NA, Lin Z, Mohanty I, Garg N, Schmidt EW, Agarwal V
JACS. 2021 143, 10221-10231
Gatekeeping ketosynthases dictate initiation of assembly line biosynthesis of pyrrolic polyketides
Yi D, Acharya A, Gumbart JC, Gutekunst WR, Agarwal V
JACS. 2021 143, 7617−7622
PDF
Yi D, Acharya A, Gumbart JC, Gutekunst WR, Agarwal V
JACS. 2021 143, 7617−7622
Enzymatic synthesis assisted discovery of proline-rich macrocyclic peptides in marine sponges
Mohanty I,* Nguyen NA,* Moore SG, Biggs JS, Gaul DA, Garg N, Agarwal V
ChemBioChem 2021 22, 2614-2618
*co-first authors
PDF
Mohanty I,* Nguyen NA,* Moore SG, Biggs JS, Gaul DA, Garg N, Agarwal V
ChemBioChem 2021 22, 2614-2618
*co-first authors
Presence of bromotyrosine alkaloids in marine sponges is independent of metabolomic and microbiome architectures
Mohanty I, Tapadar S, Moore SR, Biggs JS, Freeman CJ, Gaul DA, Garg N, Agarwal V
mSystems. 2021 6(2):e01387-20
PDF
Mohanty I, Tapadar S, Moore SR, Biggs JS, Freeman CJ, Gaul DA, Garg N, Agarwal V
mSystems. 2021 6(2):e01387-20
Stereochemical assignment and absolute abundance of non-proteinogenic amino acid homoarginine in marine sponges
Mohanty I, Moore SG, Biggs JS, Freeman CJ, Gaul DA, Garg N, Agarwal V
ACS Omega 2021 6, 33200-33205.
PDF
Mohanty I, Moore SG, Biggs JS, Freeman CJ, Gaul DA, Garg N, Agarwal V
ACS Omega 2021 6, 33200-33205.
Obligate brominating enzymes underlie bromoform production by marine cyanobacteria
Thapa HR, Agarwal V
J Phycol. 2021 57, 1131-1139
PDF
Thapa HR, Agarwal V
J Phycol. 2021 57, 1131-1139
Precursor-guided mining of marine sponge metabolomes lends insight into biosynthesis of pyrrole-imidazole alkaloids
Mohanty I, Moore SG, Yi D, Biggs JS, Gaul DA, Garg N, Agarwal V
ACS Chem Biol. 2020 15(8), 2185-2194
PDF
Mohanty I, Moore SG, Yi D, Biggs JS, Gaul DA, Garg N, Agarwal V
ACS Chem Biol. 2020 15(8), 2185-2194
Genetic and biochemical reconstruction of bromoform biosynthesis in Asparagopsis lends insights in seaweed ROS enzymology
Thapa HR, Lin Z, Yi D, Smith JW, Schmidt EW, Agarwal V
ACS Chem Biol. 2020 15(6), 1662-1670
PDF
Thapa HR, Lin Z, Yi D, Smith JW, Schmidt EW, Agarwal V
ACS Chem Biol. 2020 15(6), 1662-1670
Multi-omic profiling of Melophlus sponges reveals diverse metabolomic and microbiome architectures that are non-overlapping with ecological neighbors
Mohanty I, Podell S, Biggs JS, Garg N, Allen EE, Agarwal V
Mar Drugs. 2020 18(2), 124
PDF
Mohanty I, Podell S, Biggs JS, Garg N, Allen EE, Agarwal V
Mar Drugs. 2020 18(2), 124
Insights into thiotemplated pyrrole biosynthesis gained by crystal structure of flavin-dependent oxidase in complex with carrier protein
Thapa HR, Robbins JM, Moore BS, Agarwal V
Biochemistry. 2019 58(7):918-929.
PDF
Thapa HR, Robbins JM, Moore BS, Agarwal V
Biochemistry. 2019 58(7):918-929.
Chemical ecology of marine sponges: new opportunities through "-omics".
Paul VJ, Freeman CJ, Agarwal V
Integr Comp Biol. 2019
PDF
Paul VJ, Freeman CJ, Agarwal V
Integr Comp Biol. 2019
Mass spectrometry-based integration and expansion of the chemical diversity harbored within a marine sponge
Cantrell TP, Freeman CJ, Paul VJ, Agarwal V*, Garg N*
J Am Soc Mass Spectrom. 2019 30(8):1373-1384
*corresponding
PDF
Cantrell TP, Freeman CJ, Paul VJ, Agarwal V*, Garg N*
J Am Soc Mass Spectrom. 2019 30(8):1373-1384
*corresponding
Sulfonation and glucuronidation of hydroxylated bromodiphenyl ethers in human liver
Cisneros KV, Agarwal V, James MO
Chemospehere. 2019 226:132-139.
PDF
Cisneros KV, Agarwal V, James MO
Chemospehere. 2019 226:132-139.
Chemoenzymatic synthesis of starting materials and characterization of halogenases requiring acyl carrier protein-tethered substrates.
Thapa HR, Lail AL, Garg N, Agarwal V
Methods Enzymol. 2018 604:333-366.
PDF
Thapa HR, Lail AL, Garg N, Agarwal V
Methods Enzymol. 2018 604:333-366.
