35.
Precursor-guided mining of marine sponge metabolomes lends insight into biosynthesis of pyrrole-imidazole alkaloids
Mohanty I, Moore SG, Yi D, Biggs JS, Gaul DA, Garg N, Agarwal V
ACS Chem Biol. 2020, accepted, in press.
PDF
Precursor-guided mining of marine sponge metabolomes lends insight into biosynthesis of pyrrole-imidazole alkaloids
Mohanty I, Moore SG, Yi D, Biggs JS, Gaul DA, Garg N, Agarwal V
ACS Chem Biol. 2020, accepted, in press.
34.
Genetic and biochemical reconstruction of bromoform biosynthesis in Asparagopsis lends insights in seaweed ROS enzymology
Thapa HR, Lin Z, Yi D, Smith JW, Schmidt EW, Agarwal V
ACS Chem Biol. 2020, 15(6), 1662-1670.
PDF
Genetic and biochemical reconstruction of bromoform biosynthesis in Asparagopsis lends insights in seaweed ROS enzymology
Thapa HR, Lin Z, Yi D, Smith JW, Schmidt EW, Agarwal V
ACS Chem Biol. 2020, 15(6), 1662-1670.
33.
Multi-Omic Profiling of Melophlus Sponges Reveals Diverse Metabolomic and Microbiome Architectures that Are Non-overlapping with Ecological Neighbors
Mohanty I, Podell S, Biggs JS, Garg N, Allen EE, Agarwal V
Mar Drugs. 2020, 18(2), 124
PDF
Multi-Omic Profiling of Melophlus Sponges Reveals Diverse Metabolomic and Microbiome Architectures that Are Non-overlapping with Ecological Neighbors
Mohanty I, Podell S, Biggs JS, Garg N, Allen EE, Agarwal V
Mar Drugs. 2020, 18(2), 124
32.
Mass spectrometry-based integration and expansion of the chemical diversity harbored within a marine sponge
Cantrell TP, Freeman CJ, Paul VJ, Agarwal V*, Garg N*
J Am Soc Mass Spectrom. 2019 Aug;30(8):1373-1384
*corresponding
PDF
Mass spectrometry-based integration and expansion of the chemical diversity harbored within a marine sponge
Cantrell TP, Freeman CJ, Paul VJ, Agarwal V*, Garg N*
J Am Soc Mass Spectrom. 2019 Aug;30(8):1373-1384
*corresponding
31.
Chemical ecology of marine sponges: new opportunities through "-omics".
Paul VJ, Freeman CJ, Agarwal V
Integr Comp Biol. 2019 Apr 3
PDF
Chemical ecology of marine sponges: new opportunities through "-omics".
Paul VJ, Freeman CJ, Agarwal V
Integr Comp Biol. 2019 Apr 3
30.
Insights into thiotemplated pyrrole biosynthesis gained by crystal structure of flavin-dependent oxidase in complex with carrier protein
Thapa HR, Robbins JM, Moore BS, Agarwal V
Biochemistry. 2019 Feb 19;58(7):918-929.
PDF
Insights into thiotemplated pyrrole biosynthesis gained by crystal structure of flavin-dependent oxidase in complex with carrier protein
Thapa HR, Robbins JM, Moore BS, Agarwal V
Biochemistry. 2019 Feb 19;58(7):918-929.
29.
Chemoenzymatic Synthesis of Starting Materials and Characterization of Halogenases Requiring Acyl Carrier Protein-Tethered Substrates.
Thapa HR, Lail AL, Garg N, Agarwal V
Methods Enzymol. 2018;604:333-366.
Chemoenzymatic Synthesis of Starting Materials and Characterization of Halogenases Requiring Acyl Carrier Protein-Tethered Substrates.
Thapa HR, Lail AL, Garg N, Agarwal V
Methods Enzymol. 2018;604:333-366.
28.
Assaying Oxidative Coupling Activity of CYP450 Enzymes
Agarwal V
Methods Enzymol. 2018;604:499-521.
Assaying Oxidative Coupling Activity of CYP450 Enzymes
Agarwal V
Methods Enzymol. 2018;604:499-521.
27.
Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges
Agarwal V, Blanton JM, Podell S, Taton A, Schorn MA, Busch J, Lin Z, Schmidt EW, Jensen PR, Paul VJ, Biggs JS, Golden JW, Allen EE, Moore BS
Nat Chem Biol. 2017 May;13(5):537-543.
Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges
Agarwal V, Blanton JM, Podell S, Taton A, Schorn MA, Busch J, Lin Z, Schmidt EW, Jensen PR, Paul VJ, Biggs JS, Golden JW, Allen EE, Moore BS
Nat Chem Biol. 2017 May;13(5):537-543.
Highlighted by the NSF
Highlighted by the NIH
Highlighted by the San Diego Union-Tribune
Highlighted by Scripps, UC San Diego
Highlighted by the NIH
Highlighted by the San Diego Union-Tribune
Highlighted by Scripps, UC San Diego
On the cover (Nature Chemical Biology, May 2017)
26.
Enzymatic halogenation and dehalogenation reactions: pervasive and mechanistically diverse
Agarwal V, Miles ZD, Winter, JC, Eustaquio AS, El Gamal AA, Moore BS
Chem Rev
Accepted, in press
Enzymatic halogenation and dehalogenation reactions: pervasive and mechanistically diverse
Agarwal V, Miles ZD, Winter, JC, Eustaquio AS, El Gamal AA, Moore BS
Chem Rev
Accepted, in press
25.
Molecular basis for the broad substrate selectivity of a peptide prenyltransferase
Hao Y, Pierce E, Roe D, Morita M, McIntosh JA, Agarwal V, Cheatham TE 3rd, Schmidt EW, Nair SK
Proc Natl Acad Sci U S A. 2016
Molecular basis for the broad substrate selectivity of a peptide prenyltransferase
Hao Y, Pierce E, Roe D, Morita M, McIntosh JA, Agarwal V, Cheatham TE 3rd, Schmidt EW, Nair SK
Proc Natl Acad Sci U S A. 2016
24.
Enzymatic reductive dehalogenation controls the biosynthesis of marine bacterial pyrroles
El Gamal AA, Agarwal V, Rahman I, Moore BS
J Am Chem Soc. 2016 Oct 12;138(40):13167-13170.
Enzymatic reductive dehalogenation controls the biosynthesis of marine bacterial pyrroles
El Gamal AA, Agarwal V, Rahman I, Moore BS
J Am Chem Soc. 2016 Oct 12;138(40):13167-13170.
23.
Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair
El Gamal AA, Agarwal V,* Diethelm S, Rahman I, Schron M, Sneed JM, Louie GV, Whalen KE, Mincer T, Noel JP, Paul VJ, Moore BS
Proc Natl Acad Sci U S A. 2016; 113(14):3797-3802.
*Equal contribution first author
Highlighted by the Faculty of 1000 (F1000)
Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair
El Gamal AA, Agarwal V,* Diethelm S, Rahman I, Schron M, Sneed JM, Louie GV, Whalen KE, Mincer T, Noel JP, Paul VJ, Moore BS
Proc Natl Acad Sci U S A. 2016; 113(14):3797-3802.
*Equal contribution first author
Highlighted by the Faculty of 1000 (F1000)
22.
Unusual flavoenzyme catalysis in marine bacteria
Teufel R, Agarwal V, Moore BS
Curr Opin Chem Biol. 2016; 31:31-39.
Unusual flavoenzyme catalysis in marine bacteria
Teufel R, Agarwal V, Moore BS
Curr Opin Chem Biol. 2016; 31:31-39.
21.
Chemoenzymatic synthesis of acyl coenzyme A substrates enables in situ labeling of small molecules and proteins
Agarwal V, Diethelm S, Ray L, Garg N, Awakawa T, Dorrestein PC, Moore BS
Org Lett. 2015; 17:4452-4455.
Chemoenzymatic synthesis of acyl coenzyme A substrates enables in situ labeling of small molecules and proteins
Agarwal V, Diethelm S, Ray L, Garg N, Awakawa T, Dorrestein PC, Moore BS
Org Lett. 2015; 17:4452-4455.
20.
Complexity of naturally produced polybrominated diphenyl ethers revealed via mass spectrometry
Agarwal V, Li J, Rahman I, Borgen M, Aluwihare LI, Biggs JS, Paul VJ, Moore BS
Environ Sci Technol. 2015;49(3):1339-46.
Complexity of naturally produced polybrominated diphenyl ethers revealed via mass spectrometry
Agarwal V, Li J, Rahman I, Borgen M, Aluwihare LI, Biggs JS, Paul VJ, Moore BS
Environ Sci Technol. 2015;49(3):1339-46.
19.
Enzymatic synthesis of polybrominated dioxins from the marine environment
Agarwal V, Moore BS
ACS Chem Biol. 2014;9(9):1980-4.
Enzymatic synthesis of polybrominated dioxins from the marine environment
Agarwal V, Moore BS
ACS Chem Biol. 2014;9(9):1980-4.
18.
Biosynthesis of polybrominated aromatic organic compounds by marine bacteria
Agarwal V, El Gamal AA, Yamanaka K, Poth D, Kersten RD, Schorn M, Allen EE, Moore BS
Nat Chem Biol. 2014;10(8):640-7.
Highlighted by UCSD Health Sciences.
Highlighted by C&EN News.
Biosynthesis of polybrominated aromatic organic compounds by marine bacteria
Agarwal V, El Gamal AA, Yamanaka K, Poth D, Kersten RD, Schorn M, Allen EE, Moore BS
Nat Chem Biol. 2014;10(8):640-7.
Highlighted by UCSD Health Sciences.
Highlighted by C&EN News.
17.
Fungal polyketide engineering comes of age
Agarwal V, Moore BS
Proc Natl Acad Sci U S A. 2014;111(34):12278-9.
Fungal polyketide engineering comes of age
Agarwal V, Moore BS
Proc Natl Acad Sci U S A. 2014;111(34):12278-9.
16.
Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation
Agarwal V, Peck SC, Chen JH, Borisova SA, Chekan JR, van der Donk WA, Nair SK
Chem Biol. 2014;21(1):125-35.
Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation
Agarwal V, Peck SC, Chen JH, Borisova SA, Chekan JR, van der Donk WA, Nair SK
Chem Biol. 2014;21(1):125-35.
15.
Exploring the substrate promiscuity of an antibiotic inactivating enzyme
Agarwal V, Gadakh B, Vondenhoff GH, Severinov K, Van Aerschot A, Nair SK
MedChemComm. 2014;5:1567-70.
Exploring the substrate promiscuity of an antibiotic inactivating enzyme
Agarwal V, Gadakh B, Vondenhoff GH, Severinov K, Van Aerschot A, Nair SK
MedChemComm. 2014;5:1567-70.
14.
Structural and biochemical basis for mannan utilization by Caldanaerobius polysaccharolyticus strain ATCC BAA-17
Chekan JR, Kwon IH, Agarwal V,* Dodd D, Revindran V, Mackie RI, Cann I, Nair SK
J Biol Chem. 2014; 289(50):34965-77.
*Equal contribution first author
Structural and biochemical basis for mannan utilization by Caldanaerobius polysaccharolyticus strain ATCC BAA-17
Chekan JR, Kwon IH, Agarwal V,* Dodd D, Revindran V, Mackie RI, Cann I, Nair SK
J Biol Chem. 2014; 289(50):34965-77.
*Equal contribution first author
13.
The RimL transacetylase provides resistance to translation inhibitor microcin C
Kazakov T, Kuznedelov K, Semenova E, Mukhamedyarov D, Datsenko KA, Metlitskaya A, Vondenhoff GH, Tikhonov A, Agarwal V, Nair S, Van Aerschot A, Severinov K
J Bacteriol. 2014;196(19):3377-85.
The RimL transacetylase provides resistance to translation inhibitor microcin C
Kazakov T, Kuznedelov K, Semenova E, Mukhamedyarov D, Datsenko KA, Metlitskaya A, Vondenhoff GH, Tikhonov A, Agarwal V, Nair S, Van Aerschot A, Severinov K
J Bacteriol. 2014;196(19):3377-85.
12.
Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis
Lee J, Hao Y, Blair PM, Melby JO, Agarwal V, Burkhart BJ, Nair SK, Mitchell DA
Proc Natl Acad Sci U S A. 2013;110(32):12954-9.
PDF
Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis
Lee J, Hao Y, Blair PM, Melby JO, Agarwal V, Burkhart BJ, Nair SK, Mitchell DA
Proc Natl Acad Sci U S A. 2013;110(32):12954-9.
11.
A microfluidic approach for protein structure determination at room temperature via on-chip anomalous diffraction
Perry SL, Guha S, Pawate AS, Bhaskarla A, Agarwal V, Nair SK, Kenis PJ
Lab Chip. 2013;13(16):3183-7.
A microfluidic approach for protein structure determination at room temperature via on-chip anomalous diffraction
Perry SL, Guha S, Pawate AS, Bhaskarla A, Agarwal V, Nair SK, Kenis PJ
Lab Chip. 2013;13(16):3183-7.
10.
Structures of cyanobactin maturation enzymes define a family of transamidating proteases
Agarwal V, Pierce E, McIntosh J, Schmidt EW, Nair SK
Chem Biol. 2012;19(11):1411-22.
PDF
Structures of cyanobactin maturation enzymes define a family of transamidating proteases
Agarwal V, Pierce E, McIntosh J, Schmidt EW, Nair SK
Chem Biol. 2012;19(11):1411-22.
9.
Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis
Agarwal V, Lin S, Lukk T, Nair SK, Cronan JE
Proc Natl Acad Sci U S A. 2012;109(43):17406-11.
PDF
Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis
Agarwal V, Lin S, Lukk T, Nair SK, Cronan JE
Proc Natl Acad Sci U S A. 2012;109(43):17406-11.
8.
Biochemical and structural insights into xylan utilization by the thermophilic bacterium Caldanaerobius polysaccharolyticus
Han Y, Agarwal V,* Dodd D, Kim J, Bae B, Mackie RI, Nair SK, Cann IK
J Biol Chem. 2012;287(42):34946-60.
*Equal contribution first author
PDF
Biochemical and structural insights into xylan utilization by the thermophilic bacterium Caldanaerobius polysaccharolyticus
Han Y, Agarwal V,* Dodd D, Kim J, Bae B, Mackie RI, Nair SK, Cann IK
J Biol Chem. 2012;287(42):34946-60.
*Equal contribution first author
7.
Structure and function of a serine carboxypeptidase adapted for degradation of the protein synthesis antibiotic microcin C7
Agarwal V, Tikhonov A, Metlitskaya A, Severinov K, Nair SK
Proc Natl Acad Sci U S A. 2012;109(12):4425-30.
Highlighted by UofI News.
PDF
Structure and function of a serine carboxypeptidase adapted for degradation of the protein synthesis antibiotic microcin C7
Agarwal V, Tikhonov A, Metlitskaya A, Severinov K, Nair SK
Proc Natl Acad Sci U S A. 2012;109(12):4425-30.
Highlighted by UofI News.
6.
Aminoacyl tRNA synthetases as targets for antibiotic development
Agarwal V, Nair SK
MedChemComm. 2012;3:887-98.
Aminoacyl tRNA synthetases as targets for antibiotic development
Agarwal V, Nair SK
MedChemComm. 2012;3:887-98.
5.
Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals
Gonzalez-Gutierrez G, Lukk T, Agarwal V, Papke D, Nair SK, Grosman C
Proc Natl Acad Sci U S A. 2012;109(16):6331-6.
PDF
Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals
Gonzalez-Gutierrez G, Lukk T, Agarwal V, Papke D, Nair SK, Grosman C
Proc Natl Acad Sci U S A. 2012;109(16):6331-6.
4.
Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase
Agarwal V, Borisova SA, Metcalf WW, van der Donk WA, Nair SK
Chem Biol. 2011;18(10):1230-40.
PDF
Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase
Agarwal V, Borisova SA, Metcalf WW, van der Donk WA, Nair SK
Chem Biol. 2011;18(10):1230-40.
3.
Structural basis for microcin C7 inactivation by the MccE acetyltransferase
Agarwal V, Metlitskaya A, Severinov K, Nair SK
J Biol Chem. 2011;286(24):21295-303.
PDF
Structural basis for microcin C7 inactivation by the MccE acetyltransferase
Agarwal V, Metlitskaya A, Severinov K, Nair SK
J Biol Chem. 2011;286(24):21295-303.
2.
Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst
McIntosh JA, Robertson CR, Agarwal V, Nair SK, Bulaj GW, Schmidt EW
J Am Chem Soc. 2010;132(44):15499-501.
Circular logic: nonribosomal peptide-like macrocyclization with a ribosomal peptide catalyst
McIntosh JA, Robertson CR, Agarwal V, Nair SK, Bulaj GW, Schmidt EW
J Am Chem Soc. 2010;132(44):15499-501.
1.
Mutational insights into the roles of amino acid residues in ligand binding for two closely related family 16 carbohydrate binding modules
Su X, Agarwal V, Dodd D, Bae B, Mackie RI, Nair SK, Cann IK
J Biol Chem. 2010;285(45):34665-76.
PDF
Mutational insights into the roles of amino acid residues in ligand binding for two closely related family 16 carbohydrate binding modules
Su X, Agarwal V, Dodd D, Bae B, Mackie RI, Nair SK, Cann IK
J Biol Chem. 2010;285(45):34665-76.